IPSS, IPSS-R und WPSS Rechner

IPSS (International Prognostic Scoring System, Greenberg et al. 2002)

Table 1: Definition of the IPSSS)

Score00,511,52,0
Medullary blasts (%)0 – 45 – 1011 – 2021 – 29
Number of Cytopenias 1)0 – 12 – 3
Cytogenetic risk group 2)LowIntermed.High

 

1) Platelets < 100.000/µl, Hemoglobin < 10 g/dl, ANC < 1.800/µl
2) Low risk = normal karyotype, 5q-, 20q-, -Y
High risk =complex karyotype (≥ 3 anomalien), chromosom 7-anomalies
Interm. risk = all other aberrations

 

Table 2: IPSS-prognostic risk categories

ScoreRisk groups
0Low risk
0,5 – 1Intermed. risk I
1,5 – 2Intermed. risk II
≥ 2,5High risk

 

IPSS-R (Revised _International Prognostic Scoring System, Greenberg et al, 2012)

Table 3: Definition of the IPSS-R

Score00,511,5234
Cytogenetic group3)very goodgoodIntermed.poorvery poor
Medullary blasts (%)< 2>2–<55–10>10
Hemoglobin>108–<10<8
Platelets>10050–<100<50
ANC>0,8<0.8

 

3) Very good = del(11q), -Y
Good = normal karyotype, del(20q), del(5q), del(12p), double including del(5q)
Intermediate = +8, del(7q), i(17q), +19, any other single or double independent clone
Poor = -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), complex: 3 abnormalities
Very poor = Complex >3 abnormalities

 

Table 4: IPSS-R prognostic risk categories and clinical outcomes

ScoreRisk groupsSurvival in years (Medians)Time to 25% AML evolution (Medians)
0–1,5Very low risk8,8Not reached
1,5–3Low5,310,8
>3–4,5Intermed.3,03,2
4,5–6High1,61,4
>6Very high0,80,73

 

WPSS (WHO adapted Prognostic Scoring System, Malcovati et al. 2007)

Table 5: Definition of the WPSS

Score0123
WHO TypeRA/RARS/5q-RCMD/RSCMDRAEB IRAEB II
Karoytype risk4)LowIntermed.High
Transfusion requirements5)No oneRegularly

 

4) Low risk = normal karyotype,del (5q),del( 20q), -Y
High risk = complex karyotype (≥ 3 anomalien), chromosom 7-anomalies
Intermediate risk = all other aberrations
5) at least 1 transfusion every 8 weeks over a period of 3 months

 

Table 6: WPSS-prognostic risk categories

ScoreRisk groups
0Very low risk
1Low risk
2Intermed. risk
3 – 4High risk
5 – 6Very high risk